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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Cytotherapy. 2015 Jul 22;17(10):1353–1364. doi: 10.1016/j.jcyt.2015.05.002

Figure 4.

Figure 4

(A) Rat TNF-α ELISA of cell culture media supernatant collected from organotypic cultures after 24 h of LPS stimulation ± human PGE2. Data are normalized to untreated LPS-stimulated OHSC and represented as mean ± SE from three experiments, each with n = 3 cultures per condition. Addition of exogenous human PGE2 significantly reduced TNF-α levels in a dose-dependent manner. *P < 0.01, **P < 0.005, ***P < 0.0001 compared with LPS + no treatment. #P < 0.01, ##P < 0.001, ###P < 0.0001 between dose groups. (B) Polynomial curve fit of data presented in A, overlaid with corresponding mean levels of PGE2 production and TNF-α reduction by monolayer and encapsulated MSCs.