Fig.2.

Mitochondrial metabolism-mediated regulation of adult neurogenesis. Schematic drawing summarizing how mitochondrial metabolism influences the distinct developmental steps of adult neurogenesis: neural stem cells (NSCs) generate actively proliferating intermediate progenitor cells (IPCs). IPCs give rise to neuronally committed neuroblasts (NBs) that differentiated into mature neurons. NSCs also generate new astrocytes. Impact of mitochondrial functions on NSC self-renewal, NSCs and IPCs proliferation, differentiation and maturation of progeny is illustrated.