Table 1.
Summary of the factors involved in the alterations of adult neurogenesis through a direct involvement of the cell cycle progression
| Experimental model | Neurogenesis in DG | Neurogenesis in SVZ | Cell cycle/molecular changes | Effect of running | Ref |
| Stroke | ↑ | ↑ | ↓ G1 phase and ↑ cell cycle reentry in SVZ⟶ expansion of progenitors after stroke; | ↑ neurogenesis ↑spatial memory ↑axon rigeneration | [67] |
| ↑ p27KIP1 and p21CIP1 in the DG and SVZ⟶ inhibition on neural regeneration after stroke; | [57, 40] | ||||
| Traumatic brain injury (TBI) | ↑ | ↑ | ↓ p27KIP1 level after TBI⟶ ↑ glia proliferation; | Not assessed | [112] |
| Epilepsy | ↑ | Not assessed | ↑ p27KIP1 ⟶ shortening cell cycle; ↑ progenitor proliferation | Not assessed | [113] |
| Alzheimer Disease | THY-TAU22 mice ↑ | Not assessed | ↑ cylin D1 ↑p21CIP1 ↑ p27KIP1 | Not assessed | [114] |
| HIV | ↓ | Not assessed | ↓ CDK5 hyperactivation | ↑ proliferation ↑arborization ↑BDNF | [115] |