Fig.1.

Overview of translational regulation taking place in the NSC lineage. Data was pooled from studies investigating cortical development, adult neurogenesis in the ventricular zone and hippocampus. Arrows represent relative estimation compared to other stages within the lineage. Question marks indicate unknown situation. Question marks next to arrows indicate likely scenario based on proliferation rate, however this is not experimentally proven. Green color marks proneurogenic factors, red color marks anti-neurogenic factors. qNSC = quiescent NSC, aNSC = active NSC, nP = neurogenic progenitor, NB = neuroblast. Major sources: Proliferation rates from Codega et al. (2014), neurons are known to be postmitotic. Marker expression and protein synthesis levels from Llorens-Bobadilla et al. (2015). mTOR activity from Paliouras et al. (2012). For more details, see the main text.