Table 2.

Studies examining the role of autophagy in adult neurogenesis

Gene	Model		Age at time	Region	Effect (increase ↑, decrease ↓,				Reference
			of disruption	SGZ/SVZ	no change ↔, not assessed (na))
			Embryo (E)	Stem Cell	Proliferation	Survival	Differentiation
			Adult (A)		Renewal
Ambra1	In vitro	Neurosphere Assay Ambra1 –/+ KO	E	SVZ	↓	↓	↓	↓	[49]
Atg5	In vivo	Retroviral Cre Floxed Atg5	A	SGZ	na	↔	↓	↔	[40]
	In vivo	Retroviral Cre Floxed Atg5/BAX KO			na	↔	rescue	↔
	In vitro	Neurosphere Assay	E	SGZ, SVZ	↔	↔	↔	↔	[50]
	In vivo	Atg5GFAP cKO
Atg7	In vitro	Neurosphere Assay	E	SGZ, SVZ	↔	↔	↔	↔	[50]
	In vivo	Atg5GFAP cKO
Atg16L1	In vitro	Neurosphere assay	E	SGZ, SVZ	↔	↔	↔	↔	[50]
	In vivo	Atg16L1GFAP cKO
	In vivo	ATG16L1 hypomorph	E	SVZ	na	↓	↔	↔	[51]
Beclin1	In vitro	Neurosphere assay	E	SVZ	↓	↓	↓	↓	[49]
	In vivo	Beclin1 –/+
FIP200	In vitro	Neurosphere assay	E	SGZ, SVZ	↓	↓	↓	↓	[47]
	In vivo	FIP200GFAP cKO
	In vivo	FIP200;Trp53 cKO			rescue	rescue	↔	↔
	In vivo	FIP200;p62 cKO			rescue	rescue	rescue	rescue	[50]