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. 2017 Nov 9;3(1):43–59. doi: 10.3233/BPL-160036

Table 1.

MicroRNAs involved in regulation of AHN

Target miRNA function Origin of Identification Reference
miR-184 Numbl Inhibits differentiation, promotes proliferation, maintenance of the neurogenic stem cell pool Mouse NSCs [56]
miR-34a Numbl Inhibits differentiation, promotes proliferation, maintenance of the neurogenic stem cell pool Mouse NPCs from embryonic cortex [57]
BCL2 Promotes apoptosis Mouse cortex/SH-SY5Y cell line [85]
Cdk-4 Inhibits cell cycle progression Primary keratinocytes [83]
Cyclin D2 Inhibits cell cycle progression Primary keratinocytes [83]
Synaptotagmin1 Inhibits synaptic development Mouse ES cells [161]
Syntaxin-1A Inhibits synaptic development Mouse ES cells [161]
miR-106b/miR-25 Cluster IGF-signaling Promotes NSPC proliferation, neuronal differentiation Mouse primary NSC culture [58]
miR-124 Sox9 Promotes neuronal differentiation Mouse NSCs [72]
STAT3 Promotes neuronal differentiation Mouse ESCs [74]
BCL2L13 Inhibits apoptosis Mouse DG [82]
Lhx2 Promotes neurite outgrowth Mouse hippocampus [93]
Rap2a Promotes dendritic branching Mouse NSCs [162]
miR-137 BCL2L13 Inhibits apoptosis Mouse DG [82]
Mib-1 Inhibits dendritic growth and spine formation Mouse hippocampus & mouse primary neuronal culture [92]
LSD1 Promotes proliferation Embryonic NSCs [64]
Ezh2 Inhibits differentiation Adult NSCs [65]
miR-9 TLX Promotes differentiation, inhibits differentiation Mouse hippocampus [63]
REST Promotes neuronal differentiation NT2 cell line [79]
Rap2a Promotes dendritic branching Mouse NCSs [162]
Stathmin Inhibits migration Human embryonic NPCs [87]
Let-7b TLX Inhibits proliferation, promotes differentiation Mouse NSCs & embryonic mouse brain [66]
Cyclin D1 Inhibits cell cycle progression Embryonic mouse brain [66]
miR-125b Nestin Promotes neuronal differentiation Rat NSPCs [70]
miR-145 Sox2 Promotes neuronal differentiation Mouse NSC [69]
miR-26b Ctdsp2 Promotes neuronal differentiation Zebrafish & P19 cells [80]
miR-19 Rapgef2 Stimulates migration Mouse hippocampus & mouse NPCs [88]
miR-379/miR410 cluster N-Cadherin Induces migration Mouse embryonic cortex [86]
miR-134 Limk1 Inhibits spinogenesis Rat hippocampus [95]
Dcx Inhibits NPC migration Primary NPCs, primary neurons, mouse embryonic cortex [163]
miR-138 APT1 Inhibits spinogenesis Mouse hippocampus [96]
miR-17/miR92 cluster PTEN Induces axonal outgrowth Rat primary cortical neurons [94]
miR-132 P250GAP Promotes spinogenesis Mouse hippocampus [98]

Overview of identified microRNAs that regulate (hippocampal) neurogenesis, their targets, their role in neurogenesis, and the origin of identification.