Table 2.
Expression during | Expression during | Predicted Biological | References | |
acute stage | chronic stage | consequence | ||
miR-184 | Up | Up | Increased proliferation | [121, 122] |
miR-106b/25 cluster | Up | Up | Increased proliferation and neuronal differentiation | [123, 132, 157] |
miR-34a | Up | Up | Increased proliferation, | [123, 124, 133] |
Increased apoptosis | ||||
miR-124 | Up | Up | Increased neuronal differentiation, | [82, 131] |
Decreased apoptosis | ||||
miR-137 | Up | Up | Increased proliferation, | [82, 129] |
Decreased apoptosis | ||||
miR-9 | Down | Up | Dynamic changes in proliferation and differentiation | [129, 130] |
Let-7b | Down | Down | Increased proliferation, Decreased differentiation | [129] |
miR-26b | Up | Up | Increased neuronal differentiation | [82, 164] |
miR-145 | Up/Down | Up/Down | Changes in neuronal differentiation | [123, 130, 165] |
miR-125b | Up | Up | Increased neuronal differentiation | [132, 166] |
miR-19 | Up | Up | Increased migration | [123] |
miR-379/410 cluster | Up | Up | Increased migration | [82, 122, 132] |
miR-138 | Down | Down | Increased spinogenesis | [82, 132] |
miR-134 | Up | Up | Decreased spinogenesis | [131] |
miR-132 | Up | Up | Increased spinogenesis | [123, 132, 167] |
Overview of differentially expressed microRNAs in epilepsy known to be involved in neurogenesis, and their (predicted) biological consequence.