Table 2.
Summary of the data from the 12 features found in positive and negative ionization modes contributing to the discrimination of endometrial tissues between endometriosis patients and healthy controls
| m/z a | tR (min)b | Metabolite | Molecular formula | Adduct | Fold changec | P valued | Adj P valuee |
|---|---|---|---|---|---|---|---|
| HILIC mode | |||||||
| 131.0462 | 10.793 | Asparagine | C4H8N2O3 | M-H | 1.44 | 0.013 | 0.0173 |
| 132.1019 | 8.833 | Leucine | C6H13NO2 | M + H | 1.68 | 0.002 | 0.0120 |
| 137.0455 | 4.431 | Hypoxanthine | C5H4N4O | M + H | 1.64 | 0.033 | 0.0360 |
| 167.0209 | 5.283 | Uric acid | C5H4N4O3 | M-H | 0.54 | 0.000 | 0.0053 |
| 267.0737 | 4.539 | Inosine | C10H12N4O5 | M-H | 1.58 | 0.037 | 0.0370 |
| 282.0844 | 6.017 | Guanosine | C10H13N5O5 | M-H | 1.55 | 0.023 | 0.0276 |
| 283.0685 | 4.771 | Xanthosine | C10H12N4O6 | M-H | 2.53 | 0.008 | 0.0137 |
| RPLC mode | |||||||
| 147.1125 | 0.696 | Lysine | C6H14N2O2 | M + H | 1.54 | 0.008 | 0.0137 |
| 175.1186 | 0.703 | L-Arginine | C6H14N4O2 | M + H | 1.41 | 0.004 | 0.0137 |
| 182.0808 | 1.091 | L-Tyrosine | C9H11NO3 | M + H | 1.47 | 0.006 | 0.0137 |
| 303.2329 | 15.245 | Omega-3 Arachidonic acid | C20H32O2 | M-H | 1.57 | 0.005 | 0.0137 |
| 478.2935 | 10.770 | LPE (18:1(9Z)/0:0) | C23H46NO7P | M-H | 1.20 | 0.013 | 0.0173 |
am/z is the detected mass to charge ratio from LC-MS/MS runs
bRetention time in minutes
cThe fold change of the endometriosis group vs the control group (a higher ratio indicates a higher level of expression of a compound in the EMS group)
dP value is the significance level of the difference between the two groups
eP values were adjusted for false discovery rate correction at the significance level of 5%
LPE lysophosphatidylethanolamine, PC phosphatidylcholine