Table 4.
Interaction between APOE and LPL SNPs and dietary factors on HDL-C and total cholesterol in the PRECISE study
| Interaction between rs320 at LPL*dietary factors on HDL-C | ||
|---|---|---|
| Interaction between SNP rs320* fat energy % intake | Interaction between SNP rs320* protein energy % intake | Interaction between SNP rs320* carbohydrate energy % intake |
| 0.003 (0.004) 0.46 |
0.002 (0.01) 0.76 |
−0.0004 (0.002) 0.87 |
| Interaction between rs320 at LPL *dietary factors on Total Cholesterol | ||
| Interaction between SNP rs320* fat energy % intake | Interaction between SNP rs320* protein energy % intake | Interaction between SNP rs320* carbohydrate energy % intake |
| 0.01(0.01) 0.27 |
−0.03 (0.02) 0.13 |
−0.01 (0.01) 0.06 |
| Interaction between rs328 at LPL *dietary factors on HDL-C | ||
| Interaction between SNP rs328* fat energy % intake | Interaction between SNP rs328* protein energy % intake | Interaction between SNP rs328* carbohydrate energy % intake |
| 0.01 (0.01) 0.09 |
−0.001 (0.01) 0.89 |
0.001 (0.003) 0.63 |
| Interaction between rs328 at LPL *dietary factors on Total Cholesterol | ||
| Interaction between SNP rs328* fat energy % intake | Interaction between SNP rs328* protein energy % intake | Interaction between SNP rs328* carbohydrate energy % intake |
| −0.002 (0.02) 0.88 |
0.003 (0.03) 0.90 |
−0.01 (0.01) 0.55 |
| Interaction between rs405509 at APOE*dietary factors on HDL-C | ||
| Interaction between SNP rs405509* fat energy % intake | Interaction between SNP rs405509* protein energy % intake | Interaction between SNP rs405509* carbohydrate energy % intake |
| 0.01 (0.01) 0.11 |
−0.001 (0.01) 0.75 |
−0.01 (0.003) 0.09 |
| Interaction between rs405509 at APOE *dietary factors on Total Cholesterol | ||
| Interaction between SNP rs405509* fat energy % intake | Interaction between SNP rs405509* protein energy % intake | Interaction between SNP rs405509* carbohydrate energy % intake |
| 0.02 (0.02) 0.39 |
−0.04 (0.03) 0.26 |
−0.01 (0.01) 0.59 |
| Interaction between rs769450 at APOE *dietary factors on HDL-C | ||
| Interaction between SNP rs769450* fat energy % intake | Interaction between SNP rs769450* protein energy % intake | Interaction between SNP rs769450* carbohydrate energy % intake |
| −0.001 (0.004) 0.88 |
0.001 (0.01) 0.88 |
0.003 (0.003) 0.19 |
| Interaction between rs769450 at APOE *dietary factors on Total Cholesterol | ||
| Interaction between SNP rs769450* fat energy % intake | Interaction between SNP rs769450* protein energy % intake | Interaction between SNP rs769450* carbohydrate energy % intake |
| −0.001 (0.01) 0.94 |
0.01 (0.02) 0.63 |
0.01 (0.01) 0.51 |
| Interaction between rs439401 at APOE *dietary factors on HDL-C | ||
| Interaction between SNP rs439401* fat energy % intake | Interaction between SNP rs439401* protein energy % intake | Interaction between SNP rs439401* carbohydrate energy % intake |
| 0.01 (0.004) 0.11 |
0.01 (0.01) 0.39 |
−0.001 (0.003) 0.64 |
| Interaction between rs439401 at APOE *dietary factors on Total Cholesterol | ||
| Interaction between SNP rs439401* fat energy % intake | Interaction between SNP rs439401* protein energy % intake | Interaction between SNP rs439401* carbohydrate energy % intake |
| 0.003 (0.01) 0.79 |
−0.02 (0.02) 0.37 |
− 0.001 (0.01) 0.89 |
| Interaction between rs445925 at APOE *dietary factors on HDL-C | ||
| Interaction between SNP rs445925* fat energy % intake | Interaction between SNP rs445925* protein energy % intake | Interaction between SNP rs445925* carbohydrate energy % intake |
| −0.003 (0.01) 0.53 |
0.01 (0.01) 0.52 |
0.0003 (0.003) 0.93 |
| Interaction between rs445925 at APOE *dietary factors on Total Cholesterol | ||
| Interaction between SNP rs445925* fat energy % intake | Interaction between SNP rs445925* protein energy % intake | Interaction between SNP rs445925* carbohydrate energy % intake |
| −0.03 (0.01) 0.05 |
0.01 (0.03) 0.66 |
0.01 (0.01) 0.36 |
| Interaction between rs405697 at APOE *dietary factors on HDL-C | ||
| Interaction between SNP rs405697* fat energy % intake | Interaction between SNP rs405697* protein energy % intake | Interaction between SNP rs405697* carbohydrate energy % intake |
| 0.01(0.004) 0.06 |
−0.002 (0.01) 0.80 |
−0.004 (0.002) 0.16 |
| Interaction between rs405697 at APOE *dietary factors on Total Cholesterol | ||
| Interaction between SNP rs405697* fat energy % intake | Interaction between SNP rs405697* protein energy % intake | Interaction between SNP rs405697* carbohydrate energy % intake |
| 0.01 (0.01) 0.22 |
−0.03 (0.02) 0.19 |
−0.003 (0.01) 0.72 |
| Interaction between rs1160985 at APOE *dietary factors on HDL-C | ||
| Interaction between SNP rs1160985* fat energy % intake | Interaction between SNP rs1160985* protein energy % intake | Interaction between SNP rs1160985* carbohydrate energy % intake |
| −0.01 (0.01) 0.08 |
−0.002 (0.01) 0.97 |
0.01 (0.004) 0.03 |
| Interaction between rs1160985 at APOE *dietary factors on Total Cholesterol | ||
| Interaction between SNP rs1160985* fat energy % intake | Interaction between SNP rs1160985* protein energy % intake | Interaction between SNP rs1160985* carbohydrate energy % intake |
| −0.01 (0.01) 0.58 |
0.05 (0.03) 0.28 |
−0.001 (0.01) 0.19 |
| Interaction between rs1064725 at APOE *dietary factors on HDL-C | ||
| Interaction between SNP rs1064725* fat energy % intake | Interaction between SNP rs1064725* protein energy % intake | Interaction between SNP rs1064725* carbohydrate energy % intake |
| −0.001 (0.01) 0.90 |
0.004 (0.02) 0.77 |
−0.002 (0.004) 0.73 |
| Interaction between rs1064725 at APOE *dietary factors on Total Cholesterol | ||
| Interaction between SNP rs1064725* fat energy % intake | Interaction between SNP rs1064725* protein energy % intake | Interaction between SNP rs1064725* carbohydrate energy % intake |
| 0.03 (0.03) 0.28 |
0.02 (0.04) 0.62 |
−0.01 (0.01) 0.48 |
| Interaction between APOE (E2, E3, and E4)*dietary factors on HDL-C | ||
| Interaction between SNP APOE (E2, E3, and E4)* fat energy % intake | Interaction between SNP APOE (E2, E3, and E4)* protein energy % intake | Interaction between SNP APOE (E2, E3, and E4)* carbohydrate energy % intake |
| −0.01 (0.01) 0.39 |
0.001 (0.01) 0.99 |
0.002 (0.003) 0.17 |
| Interaction between APOE (E2, E3, and E4)*dietary factors on Total Cholesterol | ||
| Interaction between SNP APOE (E2, E3, and E4)* fat energy % intake | Interaction between SNP APOE (E2, E3, and E4)* protein energy % intake | Interaction between SNP APOE (E2, E3, and E4)* carbohydrate energy % intake |
| −0.03 (0.02) 0.18 |
−0.02 (0.04) 0.32 |
0.01 (0.01) 0.51 |
Values represented β regression coefficients (± S.E), and Pinteraction. P values were obtained by using a general linear model adjusted for age, sex, body mass index, country and total energy intake, wherever appropriate
Bonferroni corrected P value < 0.001 was considered statistically significant
HDL-C High density lipoprotein cholesterol