Table 1.
Demographic and clinical data
| Control Subjects n = 52 |
TS COPD n = 49 |
BS COPD n = 31 |
TS + BS COPD n = 46 |
|
|---|---|---|---|---|
| Sex, Male (%)/Female (%) | 15(29) / 37(71) | 35(71) / 14(29) | 12(39) / 19(61) | 26(63) / 20(37) |
| Age, years | 70.34 ± 5.95 | 69.41 ± 8.69 | 72.29 ± 9.49 | 69.93 ± 7.19 |
| Smoking history, pack-years | – | 41.57 ± 25.62 | – | 55.46 ± 47.12 |
| Biomass exposure, hour-years | – | – | 340.90 ± 206.09 | 345.15 ± 193.16 |
| Scolarship, years | 13.21 ± 2.06 | 7.56 ± 4.25 a | 5.20 ± 3.59 a, b | 6.09 ± 3.93 a, b |
| BMI, kg/m2 | 30.09 ± 5.54 | 27.67 ± 5.08 a | 26.57 ± 3.06 a | 27.35 ± 5.69 a |
| Exacerbations in the previous year | – | 1.10 ± 1.37 | 0.58 ± 0.42 | 0.69 ± 1.29 |
| FEV1, % predicted | 110.19 ± 17.46 | 56.88 ± 19.37 a, c | 68.09 ± 32.30 a | 53.79 ± 18.67 a, c |
| FEV1/FVC, % | 84.46 ± 4.24 | 54.25 ± 11.17 a | 58.39 ± 8.62 a | 53.53 ± 12.35 a, c |
| DLCO, % predicted | 81.52 ± 21.21 | 66.60 ± 19.82 a | 73.73 ± 17.16 | 61.22 ± 24.98 a, c |
| Oxygen Saturation, % | 96.91 ± 1.36 | 92.65 ± 4.55 a | 93.94 ± 4.04 a | 90.52 ± 4.90 a, b, c |
| 6 MW, meters | 492.48 ± 78.51 | 355.96 ± 163.02 a | 375.29 ± 143.75 a | 344.09 ± 161.12 a |
| mMRC | – | 2.38 ± 1.47 | 2.37 ± 1.16 | 2.67 ± 1.03 |
| CAT | – | 15.49 ± 8.21 | 14.84 ± 6.69 | 13.18 ± 6.69 |
| BODE | – | 2.88 ± 5.71 | 2.71 ± 6.35 | 3.87 ± 7.72 |
Data presented as mean ± standard deviation, unless otherwise indicated. Definition of abbreviations: BMI body-mass index, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, DLCO carbon monoxide diffusing capacity, 6 MW 6 min walking test, mMRC modified Medical Research Council scale, CAT COPD assessment test, BODE Body-mass, airflow Obstruction, Dyspnea and Exercise index
aDifferent from control subjects (p < 0.05, by ANOVA)
bDifferent from TS COPD (p < 0.05, by ANOVA)
cDifferent from BS COPD (p < 0.05, by ANOVA)