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. 2018 May 1;20:10. doi: 10.1186/s12575-018-0073-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Anti-ITGA2 antibody reduced cell migration of AGS cells through down-regulation of Rac1 and CDC42 signaling pathway. a Gene expression of LIMK, Rac1, PAK, CDC42 and N-WASP in AGS after treatment with 0.1 μg anti-ITGA2 antibodies or isotype control antibodies (negative control) for 18 h. Each analysis was derived from the same experiment and gels were processed in parallel. Cropped gels are displayed for comparison between gene expressions in different groups. b Densitometric measurements on the intensities of each RT-PCR product was normalized to the mRNA level of GAPDH, and displayed as mean ± standard deviation (S.D). Statistical comparisons were made by two-way ANOVA with Bonferroni comparisons. ** p < 0.01 and **** p < 0.0001. c Summary of the anti-ITGA2 antibody-mediated migration signaling pathway in AGS gastric cancer cells