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LNIO inhibited the protein expression of NOS3 in MCF-7/MDR cells. (A) NOS3 expression in MCF-7/MDR and MCF-7 cells was detected by western blot analysis. (B) NOS3 protein expression under different concentrations of LNIO was detected by western blot analysis in MCF-7/MDR cells. *P<0.05 and **P<0.01 as indicated. LNIO, L-N5-(1-Iminoethyl)-ornithine hydrochloride; NOS3, nitric oxide synthase 3; MDR, multidrug resistance.
