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Inhibition of brain-derived neurotrophic factor decreased the IC50 of MCF-7/MDR cells in response to various anticancer drugs.
| IC50 value | |||
|---|---|---|---|
| Anticancer drug | MCF-7/MDR | MCF-7/MDR+ANA-12 | P-value |
| ADM, µM | 43.98±1.52 | 16.80±2.07 | 0.0000521 |
| DDP, µg/ml | 6.49±0.17 | 6.78±0.19 | 0.1182792 |
| 5-FU, µg/ml | 7.06±0.41 | 4.74±0.67 | 0.0007725 |
MDR, multidrug resistance; ADM, adriamycin; DDP, cisplatin; 5-FU, 5-fluorouracil.
