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. 2018 Mar 9;17(5):6301–6310. doi: 10.3892/mmr.2018.8713

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Copyright: © Qiu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 10. — TGF-β inhibitor reversed the effects of miR-214-5p downregulation on the mRNA expression of ALP, Runx2, OC and COL1. Reverse transcription-quantitative polymerase chain reaction demonstrated that TGF-β inhibitor reversed the anti-miR-214-5p-induced increases in the mRNA expression of (A) ALP, (B) Runx2, (C) OC and (D) COL1 in human bone marrow stem cells. ##P<0.01 vs. negative control group; **P<0.01 vs. anti-miR-214-5p group. TGF-β, transforming growth factor-β; miR, microRNA; ALP, alkaline phosphatase; Runx2, runt-related transcription factor 2; OC, osteocalcin; COL1A1, collagen type IV α1 chain; negative, negative control transfection group; anti-miR-214-5p group, miR-214-5p downregulation group; TGF-β inhibitor group, miR-214-5p downregulation+TGF-β inhibitor group.