Figure 7.

Effects of PHC treatment on alterations in NF-κB and AP-1 activation in the lungs of rats subjected to THS. Electrophoretic mobility shift assay analysis demonstrated decreased activity of (A) NF-κB and (B) AP-1 in the lung tissues of the sham group. By contrast, significantly higher activity levels of NF-κB and AP-1 were observed in the THS group. Compared with the THS group, the activity of NF-κB and AP-1 was decreased in lung tissues from the PHC group. *P<0.05 vs. sham group; ^#P<0.05 vs. THS group. The data are presented as the mean ± standard deviation (n=10). THS, blunt chest trauma with hemorrhagic shock; PHC, penehyclidine hydrochloride; NF-κB, nuclear factor-κB; AP-1, activator protein-1.