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. 2018 Mar 7;17(5):6397–6404. doi: 10.3892/mmr.2018.8697

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Effects of miR-3147 on vulvar carcinoma in vitro. Overexpression of miR-3147 (A) increased the rate of growth, (B) promoted EMT and increased levels of MMP-2 and MMP-9, (C) decreased downstream target genes of Smad4, (D) increased migration, (E) increased invasion (scale bars, 200 µm) and (F) promoted G1/S progression. *P<0.05 vs. ctrl. miR, microRNA; Ctrl, control; EMT, epithelial-mesenchymal transition; MMP, matrix metalloproteinase; Bax, B-cell lymphoma 2-associated X protein; Bim, B-cell lymphoma-2-like protein 11; PAI-1, plasminogen activator inhibitor-1.