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. 2018 Mar 7;17(5):6397–6404. doi: 10.3892/mmr.2018.8697

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Effects of Smad4 on vulvar carcinoma in vitro. Downregulated expression of Smad4 (A) increased the rate of growth, (B) decreased Smad4 mRNA expression, (C) decreased Smad4 protein expression, (D) increased migration, (E) increased invasion (scale bars, 200 µm) and (F) promoted G1/S progression. *P<0.05 vs. ctrl. siR, small interfering RNA; Ctrl, control.