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. 2018 Mar 7;17(5):6397–6404. doi: 10.3892/mmr.2018.8697

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — miR-3147 downregulated Smad4. (A) The miRanda website predicted that the Smad4 mRNA 3′ untranslated region contained miR-3147 binding sites. (B) Overexpression of miR-3147 increased Smad4 mRNA. (C) Overexpression of miR-3147 decreased Smad4 protein levels. (D) Reduced expression of Smad4 increased miR-3147 mRNA levels. (E) Luciferase reporter assays confirmed that Smad4 was the target of miR-3147. *P<0.05 vs. ctrl. miR, microRNA; Ctrl, control.