Table II.
The top 15 enrichedgene ontology terms of up-regulated DEGs and downregulated DEGs.
| A, The top 15 enriched gene ontology terms of the upregulated DEGs | |||
|---|---|---|---|
| Category | Term | Count | P-value |
| BP | Cell division | 47 | 2.13E-28 |
| BP | Mitotic nuclear division | 28 | 7.12E-15 |
| BP | sSster chromatid cohesion | 19 | 6.92E-14 |
| BP | G1/S transition of mitotic cell cycle | 17 | 9.83E-12 |
| BP | Cell proliferation | 28 | 7.54E-11 |
| CC | Nucleoplasm | 97 | 6.57E-14 |
| CC | Condensed chromosome kinetochore | 17 | 6.24E-13 |
| CC | Midbody | 19 | 3.04E-12 |
| CC | Spindle pole | 16 | 2.50E-10 |
| CC | Kinetochore | 14 | 5.65E-10 |
| MF | Protein binding | 198 | 6.15E-12 |
| MF | Protein kinase binding | 27 | 4.95E-10 |
| MF | ATP binding | 51 | 5.69E-07 |
| MF | Microtubule binding | 14 | 3.52E-05 |
| MF | Microtubule motor activity | 8 | 3.11E-04 |
| B, The top 15 enriched gene ontology terms of the down-regulated DEGs | |||
| Category | Term | Count | P-value |
| BP | Extracellular matrix organization | 45 | 1.92E-19 |
| BP | Platelet degranulation | 27 | 2.96E-13 |
| BP | Cell adhesion | 58 | 1.86E-12 |
| BP | Muscle organ development | 20 | 9.72E-09 |
| BP | Muscle contraction | 21 | 4.34E-08 |
| CC | Proteinaceous extracellular matrix | 60 | 9.31E-26 |
| CC | Extracellular matrix | 62 | 5.68E-25 |
| CC | Extracellular space | 132 | 2.99E-19 |
| CC | Extracellular region | 145 | 6.81E-18 |
| CC | Sarcolemma | 26 | 1.01E-14 |
| MF | Heparin binding | 37 | 1.33E-16 |
| MF | Integrin binding | 26 | 1.77E-12 |
| MF | Extracellular matrix binding | 11 | 5.86E-08 |
| MF | Actin binding | 34 | 1.34E-07 |
| MF | Calcium ion binding | 62 | 2.85E-07 |
DEG, differentially expressed gene; BP, biological process; CC, cellular component; MF, molecular function.