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. 2018 Mar 9;17(5):6379–6386. doi: 10.3892/mmr.2018.8726

Table I.

Enriched Gene Ontology terms for upregulated and downregulated differentially expressed genes.

A, Upregulated

Term Gene function Count P-value
GO:0007067 Mitosis 14 6.11×10‒13
GO:0000280 Nuclear division 14 6.11×10‒13
GO:0000087 M phase of mitotic cell cycle 14 7.70×10‒13
GO:0048285 Organelle fission 14 1.02×10‒12
GO:0000279 M phase 15 6.02×10‒12
GO:0022403 Cell cycle phase 16 9.16×10‒12
GO:0000278 Mitotic cell cycle 15 2.91×10‒11
GO:0022402 Cell cycle process 16 7.21×10‒10
GO:0007049 Cell cycle 16 5.28×10‒08
GO:0051301 Cell division 11 8.09×10‒08
GO:0065004 Protein-DNA complex assembly   5 3.22×10‒04
GO:0007018 Microtubule-based movement   5 7.32×10‒04
GO:0007017 Microtubule-based process   6 2.14×10‒03
GO:0034622 Cellular macromolecular complex assembly   6 5.69×10‒03
GO:0051726 Regulation of cell cycle   6 6.72×10‒03
GO:0034621 Cellular macromolecular complex subunit organization   6 9.16×10‒03
GO:0008283 Cell proliferation   6 2.02×10‒02

B, Downregulated

Term Gene function Count P-value

GO:0032870 Cellular response to hormone stimulus   6 1.73×10‒05
GO:0001525 Angiogenesis 10 3.41×10‒05
GO:0050900 Leukocyte migration   7 2.53×10‒04
GO:0030336 Negative regulation of cell migration   6 6.18×10‒04
GO:0042493 Response to drug   9 1.62×10‒03
GO:0007165 Signal transduction 18 3.98×10‒03
GO:0007155 Cell adhesion 10 5.99×10‒03
GO:0016337 Single organismal cell-cell adhesion   5 6.12×10‒03
GO:0002576 Platelet degranulation   5 6.56×10‒03
GO:0006898 Receptor-mediated endocytosis   6 1.12×10‒02
GO:0043065 Positive regulation of apoptotic process   7 2.15×10‒02
GO:0018108 Peptidyl-tyrosine phosphorylation   5 2.48×10‒02
GO:0045893 Positive regulation of transcription, DNA-templated   9 3.28×10‒02
GO:0045087 Innate immune response   8 3.61×10‒02
GO:0006810 Transport   7 4.02×10‒02

Count, the number of enriched genes in each term.