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. 2018 Mar 7;17(5):6506–6514. doi: 10.3892/mmr.2018.8696

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — POD-NLC inhibits cell proliferation in VK2/E6E7 cells. (A) Comparison of inhibitory effects of different concentrations of POD-NLC and free-POD following 48 h of treatment. Ns, no significant difference vs. POD group; *P<0.05 and **P<0.01 vs. corresponding POD group. (B) Comparison of inhibitory effects of 5 µg/ml POD-NLC and free-POD-T following 24, 48 and 72 h of treatment. **P<0.01 vs. the POD group. (C) Morphological alterations of VK2/E6E7 cells incubated with normal saline (control), 0.05 µg/ml POD-NLC or 0.05 µg/ml POD for 48 h were observed by a fluorescence microscopy (Hoechst 33342; magnification, ×400). (D) The total number of apoptotic cells and the percentage of the late and early apoptotic cells were quantified. (E) Percentage of VK2/E6E7 cells in different phases of the cell cycle. The number of VK2/E6E7 cells in the G0-G1, S and G2-M phases and the corresponding percentage values were calculated for normal saline, 0.05 µg/ml POD-NLC and 0.05 µg/ml POD-T groups following 48 h of treatment. **P<0.01 vs. the control (normal saline) group; ^##P<0.01 vs. the POD group.