Table I.
Effects of atorvastatin on Fn (mg/l) and Col IV (µg/l) in human mesangial cells.
| Group | Fn (mg/l) | Col IV (µg/l) |
|---|---|---|
| Control | 3.90±0.43 | 4.54±0.74 |
| HG+LPC | 7.89±0.34a | 16.32±1.55a |
| HG+LPC+atorvastatin | 5.17±0.34b | 10.80±1.70b |
a
P<0.05 vs. control group
b
P<0.05 vs. HG+LPC group. Each group was cultured for 24 h and the experiment was repeated three times. Fn and Col IV levels in cell culture supernatants were detected by ELISA. Fn, fibronectin; Col IV, collagen IV; HG, high glucose; LPC, lysophosphatidylcholine.