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. 2018 Mar 1;17(5):6526–6532. doi: 10.3892/mmr.2018.8663

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Copyright: © Long et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — PTEN mRNA is a specific binding molecule of miR-367 in A375 cells. (A) miR-367 and its predicted targeting region for wild PTEN. (B) miR-367 suppressed luciferase reporter activities of PTEN in wild-type, but had no significant effect on that of PTEN in mutated type. (C) Tumor weight was markedly raised in miR-367 group compared with miR-control group. (D) Tumor volume was significantly increased in miR-367 group compared with miR-control group. (E) PTEN expression was shown in xenograft tumors. (F) PTEN expression in miR-367 mimics group was distinctly lower than that in miR-control group. (G) The level of miR-367 was elevated in miR-367 mimics group compared with miR-control group. *P<0.05, compared with miR-control group. miR, microRNA; PTEN, phosphatase and tensin homolog.