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. 2018 Mar 1;17(5):6526–6532. doi: 10.3892/mmr.2018.8663

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Copyright: © Long et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Forced expression of PTEN attenuated the enhancing effect of miR-367 on the proliferation and migration of A375 cells. (A) Transfection of miR-367 inhibited PTEN expression, increased the phosphorylation of AKT and increased cell growth in A375 cells, but the cotransfection of PTEN vectors attenuated these functions of miR-367 mimics in A375 cells. (B) Forced expression of miR-367 mimics enhanced the invasion and migration of A375 cells, but upregulation of PTEN limited partially the ability of invasion and migration of A375 cells transfected with miR-367 mimics. *P<0.01 compared with empty vectors group; ^#P<0.05 compared with miR-367 mimics group. miR, microRNA; PTEN, phosphatase and tensin homolog; AKT, protein kinase B.