Figure 3.
YC-1 reduced brain infarction in mice subjected to transient middle cerebral artery occlusion. Delayed treatment of YC-1 (25 mg/kg) at 3 h only, significantly reduced brain infarction when compared with controls. The infarct volumes are expressed as a percentage of the contralateral hemisphere (control n=10; YC-1 1 h, n=10; YC-1 2 h, n=7; YC-1 3 h, n=9; YC-1 4 h, n=7). *P<0.05 vs. control (polyethylene glycol 400-treated). YC-1, 3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole; n, number of mice.