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Concentration of Aβ1–42 in the WT and AD mouse brain cortex at early and progressed stages of AD. Mice at 8-months of age were considered to be early stage AD mice and 12-month-old mice were used as progressed AD stage mice. Data are presented as the mean ± standard deviation. **P<0.01 vs. WT mice at the same age. Aβ, amyloid β; WT, wild-type; AD, Alzheimer's disease; mo, months.
