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. 2018 Mar 14;17(5):6969–6976. doi: 10.3892/mmr.2018.8741

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Analysis the efficacy of Tan-IIA on bone-resorbing activity and apoptosis of osteoclasts. (A) Apoptotic index of osteoblasts induced by RANKL following treatment with Tan-IIA, ADN or PBS. (B) Relative mRNA levels of caspase-3 in osteoblasts. (C) Relative mRNA levels of Apaf-1 in osteoblasts. (D) Gene expression levels of anti-apoptotic Bcl-2 in osteoblasts. (E) Gene expression levels of anti-apoptotic p53 in osteoblasts. (F) Bone resorbing activity of osteoblasts following treatment with Tan-IIA, ADN or PBS. Data are presented as the mean ± standard error of the mean. **P<0.01. ADN, alendronate; Tan-IIA, tanshinone IIA; RANKL, receptor activator of NF-κB ligand; Apaf-1, apoptotic protease-activating factor 1; Bcl-2, B-cell lymphoma 2.