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. 2018 Mar 15;17(5):7081–7088. doi: 10.3892/mmr.2018.8749

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Copyright: © De Felice et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Upregulated apoptotic genes in keloid fibroblasts following IM treatment. Significant upregulation of the expression of apoptotic genes, was evaluated by quantitative polymerase chain reaction in 1 µmol IM treated keloid fibroblasts following 72 h of treatment. *P<0.05 vs. untreated cells. IM, Ingenol Mebutate; BIRC3, baculoviral IAP repeat-containing protein 3; CASP, caspase; CD, cluster of differentiation; CD40LG, CD40 ligand; CIDEA, cell death inducing DFFA-like effector A; TP53, tumor protein p53; TP53BP2, TP53 binding protein 2; B2 M, β-2-microglobulin.