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IM induced apoptosis in keloid fibroblasts through caspase-3 activation. Following incubation with 1 µmol of IM for 48 and 72 h the enzymatic activity was measured by a quantitative colorimetric caspase-3 activity assay. ***P<0.001 vs. 72 h untreated keloid cells. IM, Ingenol Mebutate.
