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PEDF-induced autophagy is dependent of the Atg5 pathway. H9c2 cells were maintained in normoxic or hypoxic conditions for 4 h with or without PEDF (10 nM). RNA interference assays were used to silence PEDF-R. Samples were collected and analyzed for the expression levels of Atg5 protein by western blotting. n=4. Atg5, autophagy related 5; Ctrl, control; PEDF-R, pigment epithelial-derived factor receptor; siPEDF, short interfering PEDF RNA.
