Table 5.

In vitro pyronaridine sensitivity of different genotyped subgroups

Group	pfmdr1 haplotype					N	Pyronaridine IC50 (nM)
	86	184	1,034	1,042	Copy no.
I	N	Y	S	N	3.0 ± 1.5	39	5.9 ± 3.4
II	N	Y	C	D	0.89	1	5.31
III	N	F	S	N	1.6 ± 1.0	61	5.1 ± 2.9
IV	N	F	S	D	2.8 ± 2.6	2	6.0 ± 0.5
V	N	F	C	D	2.0 ± 1.2	5	5.3 ± 2.0
VI	Y	Y	S	N	1.9 ± 1.2	9	7.8 ± 3.4
VII	Y	F	S	N	1.40	1	5.56

Significant difference among groups (P = 0.378, one-way analysis of variance).