Table 3.
Determinants of IgG reactivity in May 2011 and 2012 by multiple regression analysis
| Coefficient | May 2011 | May 2012 | ||
|---|---|---|---|---|
| Estimate | Pr (> |t|) | Estimate | Pr (> |t|) | |
| (Intercept) | 5.44E−01**** | < 2.00E−16 | 4.53E−01**** | < 2.00E−16 |
| Segment SNPs per kb | −4.07E−05 | 9.12E−01 | −2.15E−04 | 4.97E−01 |
| Location [intracellular region] | −3.37E−01**** | 3.30E−10 | −2.81E−01**** | 7.57E−10 |
| Location [plasma membrane] | −7.70E−01**** | 7.47E−12 | −6.17E−01**** | 1.08E−10 |
| Segment SNPs per kb*location [intracellular region] | 1.46E−03 | 1.01E−01 | 1.39E−03 | 6.75E−02 |
| Segment SNPs per kb*location [plasma membrane] | 1.43E−02**** | 3.18E−11 | 1.13E−02**** | 7.75E−10 |
| Multiple R2 | 0.199 | 0.172 | ||
| (Intercept) | 2.99E−01**** | < 2e−16 | 2.54E−01**** | < 2e−16 |
| Segment SNPs per kb | 1.75E−03**** | 4.07E−10 | 1.28E−03**** | 7.10E−08 |
| Has ortholog | −3.13E−02 | 4.37E−01 | −3.02E−02 | 3.74E−01 |
| MW | −2.67E−07**** | 8.58E−08 | −2.23E−07**** | 1.32E−07 |
| Has ortholog*MW | 3.00E−07*** | 3.95E−04 | 2.56E−07*** | 3.56E−04 |
| Segment SNPs per kb*has ortholog | −1.99E−03* | 4.10E−02 | −1.46E−03 | 7.64E−02 |
| Multiple R2 | 0.0685 | 0.0572 | ||
IgG = immunoglobulin G; MW = molecular weight; SNP = single nucleotide polymorphism. Estimations of coefficients in two multiple regression models of normalized mean IgG reactivity with covariates of SNPs/kb and subcellular location in the first model, and presence of ortholog, molecular weight, and SNPs/kb in linear combination with interaction variables identified by Pearson χ2 analysis and bidirectional stepwise regression from 267 subjects in May 2011 and 234 of the same subjects in May 2012.
****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05.