Table 7.
HRs of patients with psychiatric disorders by medication use compared with patients with oral prednisolone use.
| Medications use | Psychiatric disorders n(%) |
Crude HR (95% CI) | Adjusted HR (95% CI) | Without prednisolone Adjusted HR (95% CI) |
With prednisolone Adjusted HR (95% CI) |
|---|---|---|---|---|---|
| Prednisolone | |||||
| Yes (n = 20,202) | 2,011 (9.95) | 0.706 (0.465–0.801)** | 0.713 (0.472–0.813)** | N/A | N/A |
| No (n = 20.203) | 2,849 (14.10) | Reference | Reference | ||
| Inhaled steroids | |||||
| Yes (n = 8,612) | 988 (11.47) | 0.942 (0.802–1.051) | 0.970 (0.834–1.167) | 0.982 (0.857–1.266) | 0.912 (0.818–1.109) |
| No (n = 31,793) | 3,872 (12.18) | Reference | Reference | Reference | Reference |
| Beta-agonist | |||||
| Yes (n = 21,720) | 2,041 (9.40) | 0.623 (0.511–0.729)*** | 0.684 (0.522–0.800)** | 0.697 (0.529–0.824)* | 0.662 (0.513–0.789)** |
| No (n = 18,685) | 2,819 (15.09) | Reference | Reference | Reference | Reference |
| Aminophylline | |||||
| Yes (n = 21,898) | 2,020 (9.22) | 0.601 (0.499–0.714)*** | 0.654 (0.513–0.824)** | 0.632 (0.492–0.810)** | 0.678 (0.527–0.883)* |
| No (n = 18,507) | 2,840 (15.35) | Reference | Reference | Reference | Reference |
| Leukotriene receptor antagonists | |||||
| Yes (n = 3,345) | 291 (8.70) | 0.706 (0.459–0.816)** | 0.710 (0.469–0.826)** | 0.709 (0.468–0.825)** | 0.712 (0.472–0.829)** |
| No (n = 37,060) | 4,569 (12.33) | Reference | Reference | Reference | Reference |
| Anti-IgE antibody | |||||
| Yes (n = 27) | 1 (3.70) | 0.308 (0.007–0.995)* | 0.420 (0.010–1.097) | 0.683 (0.145–2.894) | No patients |
| No (n = 40,378) | 4,859 (12.03) | Reference | Reference | Reference | Reference |
Adjusted HR, adjusted hazard ratio: adjusted for the variables listed in Table 1; CI, confidence interval.
*p < 0.05.
**p < 0.01.
***p < 0.001.