Figure 3.

Sustained release of cannabinoid (CBD). (A) One design of multifunctional smart biomaterial (SRB) made of Food and Drug Administration-approved biocompatible biodegradable polymer loaded with a payload of CBDs/nanoparticles (NPs); (B) actual SRBs with payload; (C,D) in vitro release of CBD payload from SRB, demonstrating the ability for (C) sustained release over many days, and (D) quick release. The release kinetics (i.e., how slow or fast) can be optimized to treatment schedules, by varying the degree of cross-linking in the polymer or the polymer weighting. (E) Computed tomography image of mouse imaged over time with small animal radiation research platform showing degradation of SRB as payload is released over time in the tumor on the right side of image. (F) Average pixel intensity from maximum amplitude image for all image slices. The data are obtained from evaluating the same region of interest in the processed maximum intensity images.