Figure 2.

Intraoperative NIRF to guide complete tumor resection (patient #9). (A) Intraoperative NIRF before tumor resection: Hyperfluorescence of a ccRCC was seen after injection of ¹¹¹In-DOTA-girentuximab-IRDye800CW. NIRF was successfully used for tumor border delineation. (B) Ex vivo NIRF of the resected specimen showed a rim of normal hypofluorescent tissue around the hyperfluorescent tumor indicating a negative surgical margin, as confirmed by histopathology. (C) Intraoperative NIRF of the surgical cavity after tumor resection indicated complete tumor removal.