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Plasma pharmacokinetic parameters of MM-DX-929 (detected by 64Cu) and 3H-MM-DX-929 (detected by 64Cu or 3H) calculated using non-compartmental analysis.
|
Compound |
Pharmacokinetics Parameters | |||
|---|---|---|---|---|
| t1/2 (h) | AUC(%i.d.h/mL) | CL (mL/h) | Vss (mL) | |
| MM-DX-929 (64Cu) | 12 ± 0.7 | 1500 ± 66 | 0.069 ± 0.003 | 1.2 ± 0.1 |
| 3H-MM-DX-929 (64Cu) | 11.6 ± 0.4 | 1400 ± 100 | 0.071 ± 0.006 | 1.1 ± 0.1 |
| 3H-MM-DX-929 (3H) | 11 ± 0.9 | 1300 ± 160 | 0.078 ± 0.010 | 1.2 ± 0.1 |
