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. 2018 Mar 21;8(9):2313–2328. doi: 10.7150/thno.22027

Figure 2.

Figure 2

In vivo fluorescence imaging of GIST-T1 tumors with IR700-12A8. (A) Representative imaging pattern of GIST-T1 xenograft in mice. IR700-12A8 (100 μg) was intravenously injected into mice with xenografted GIST-T1 cells and fluorescence images were acquired using an IVIS Spectrum. The yellow arrows indicate GIST-T1 tumors. (B) Representative fluorescence images of mice implanted with GIST-T1 cells (right flank, orange arrow) and with SW620 cells (left flank, blue arrow) as a negative control tumor. (C) Chronological changes of the mean IR700 fluorescence intensity in GIST-T1 tumors, SW620 tumors, and background skin. The regions of interest (ROIs) with a diameter of 7 mm were placed in each of the 5 tumors and the opposite side of background skin, and the mean fluorescence intensities were calculated using software provided by the manufacturer. Data represent mean ± SD (n=5; *p<0.05, **p<0.01 by Dunnett's test). (D) Signal to noise (S/N) ratio of IR700 fluorescence in GIST-T1 and SW620 xenograft mice. Data represent mean ± SD (n=5; *p<0.05, **p<0.01 by Student's t test).