Table 1.
Biodistribution of i.v.-administered 99mTc-Cy50.5CD10PIBMA39 and i.v.- or locally administered 99mTc-MAA-Ad.
| Reference distribution host | Reference distribution guest | ||
|---|---|---|---|
|
Tissue |
99mTC-Cy50.5CD10PIBMA mean |
Model I: 99mTc-MAA-Ad mean | Model II: 99mTc-MAA-Ad mean |
| Blood | 2.4 ± 1.3 | 2.7 ± 0.9 | 1.0 ± 0.6 |
| Lungs | 1.7 ± 0.5 | 335.8 ± 38.7 | 4.4 ± 1.2 |
| Spleen | 0.9 ± 0.4 | 0.9 ± 0.2 | 6.1 ± 2.4 |
| Liver | 1.0 ± 0.2 | 1.3 ± 0.4 | 50.4 ± 15.4 |
| Kidneys | 4.7 ± 1.3 | 1.8 ± 0.6 | 15.3 ± 2.7 |
| Muscle | 0.4 ± 0.2 | 0.3 ± 0.1 | 0.9 ± 0.3 |
| Brain | 0.1 ± 0.0 | 0.1 ± 0.1 | 0.2 ± 0.1 |
Data were calculated based on the radioactive counts measured in various tissues at 2 h post-injection of the radioactive tracer expressed as the mean of the percentage of the injected dose per gram tissue (%ID/g) of 5 observations.