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. 2018 Mar 23;8(9):2387–2406. doi: 10.7150/thno.23620

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Resveratrol improves mitochondrial functionality and transcription in BMMSCs derived from SAMP6 mice. (A) Quantitative analysis of ATP production versus ADP ratio in BMMSCs. (B, C) DCFDA detection of total ROS level in BMMSCs (B) with flow cytometric quantitative analysis of fluorescence intensity (C). Bars: 10 μm. (D, E) Rhodamine 123 detection of mitochondrial membrane potential of BMMSCs (D) with quantitative analysis of fluorescence intensity (E). Bars: 10 μm. (F) Kinetic analysis of oxygen consumption as an index of mitochondrial OXPHOS activity in cultured BMMSCs. (G, H) qRT-PCR analysis of mRNA expression levels of nuclear-encoded (G) and mtDNA-encoded (H) gene representatives for mitochondrial complex subunits of BMMSCs. BMMSCs from 4-month-old SAMP6 mice were treated with either resveratrol (10 μM) or the DMSO (0.001%) solvent control. n = 3 per group. Data represent mean ± SD. *P < 0.05; NS, not significant (P > 0.05). Data were analyzed using ANOVA followed by Newman-Keuls post-hoc tests.