Figure 2.

Toddler is an embryonic signal that promotes cell internalization and migration during the embryogenesis of zebrafish. Toddler is annotated as a lncRNA ENSDARG00000094729. It contains a 58-aa smORF and is also capped and polyadenylated, so it can be caught by ribosome and produce peptides named Toddler. The normal expression of Toddler can promote cell internalization and migration during the embryogenesis of zebrafish via the G-protein-coupled APJ/Apelin receptor. However, the overexpression or inhibition of Toddler will inhibit cell internalization and migration.