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. 2018 Mar 28;8(9):2496–2507. doi: 10.7150/thno.24677

Figure 8.

Figure 8

Working model for HOXB-AS3 peptide. Instead of functioning by lncRNA directly, the peptide derived from HOXB-AS3 competitively binds to the arginine residues in RGG motif of hnRNP A1 and antagonizes the hnRNP A1-mediated regulation of pyruvate kinase M (PKM) splicing by blocking the binding of the arginine residues in RGG motif of hnRNP A1 to the sequences flanking PKM exon 9, ensuring the formation of lower PKM2 and suppressing glucose metabolism reprogramming. (hnRNP: heterogeneous nuclear ribonucleoprotein; HOXB-AS3: HOXB cluster antisense RNA 3; PKM: pyruvate kinase M; RGG: Arg-Gly-Gly; TCA cycle: tricarboxylic acid cycle). Adapted with the permission from ref 117, copyright 2016 Elsevier.