Table 1.
Types of ncRNAs and their basic features.
Name | Abbreviation | Size | Location | Functions | Examples | Database | References |
---|---|---|---|---|---|---|---|
Ribosomal RNAs | rRNAs | 6.9 kb | rDNA | Composition of ribosome | \* | NONCODE database | 14 |
Transfer RNAs | tRNAs | <0.1 kb | tDNA | Amino acid transport | \* | NONCODE database | 15 |
Small nucleolar RNAs | snoRNAs | 60 to 300 bp | Intronic | Important function in the maturation of other ncRNAs/Association with development of some cancers | U50, S NORD | Starbase, PITA | 26 |
Small nuclear RNAs | snRNAs | 100 to 200 bp | \* | mRNAs splicing | U3, U6 | miRanda | 42 |
MicroRNAs | miRNAs | 19 to 24 bp | Widespread loci | Targeting of mRNAs and many others/ Initiation of various disorders including many cancers | let-7 | miRmap, miRSNP, MirBase |
36 |
Transcribed ultraconserved regions | T-UCRs | >200 bp | Widespread loci | Regulations of miRNA and mRNA levels/Possible involvement in tumorigenesis | UCR106 | ncRNA.org | 112 |
PIWI-interacting RNAs | piRNAs | 26 to 31 bp | Clusters, intragenic | Transposon repression or relationship with diseases has not been discovered | MIWI, MILI, MIWI2 | piRNA BANK | 23 |
Circular RNAs | circRNAs | ~500 bp | Widespread loci | As endogenous competitive RNA/Association with many cancers and diseases | ciRs7, cANRIL | circRNAbase | 25 |
Long non-coding RNAs | lncRNAs | >200 bp | Widespread loci | Scaffold DNA-chromatin complexes, X-chromosome inactivation/Involved in tumorigenesis and cancer metastasis | H19, XIST, HOTAIR, TSIX |
lncRNA database, 3.0, LNCipedia | 19 |
*No reference data.