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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Cell Rep. 2018 Apr 17;23(3):701–708. doi: 10.1016/j.celrep.2018.03.094

Figure 4. TMEM150C Potentiates MA Current of Potassium-Selective TREK-1 Channel.

Figure 4

(A) Exemplar cell-attached MA current traces recorded in HEK293TΔP1 cells in response to application of a negative pressure in the pipette using a high-speed pressure clamp (Ehold = 0 mV). Each pressure step was preceded by a 500-ms step at 5 mmHg to remove inactivation.

(B) Quantification of peak MA potassium current amplitude measured at Ehold = 0 mV at different pressures. Data shown as mean ± SEM.

(C and D) Quantification of cell-attached MA current activation threshold (C) and average inactivation rate (D). NS, not significant; p > 0.05, **p < 0.01, Mann-Whitney U test. Data shown as mean ± SEM.

See also Figures S2C and S3C.