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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Biopharm Drug Dispos. 2018 Apr;39(4):218–231. doi: 10.1002/bdd.2128

Figure 5.

Figure 5

3D mesh plot illustrating the effects of renal function (100%–10%) on renal clearance (CLR) of GHB (1500 mg/kg single IV bolus dose), when (1) expression of renal transporters is altered (VMAX, BBM and VMAX, BLM parameters were perturbed ± 0, 2, and 5-fold) and (2) DDI is present as non-competitive inhibition of GHB renal reabsorption (R = [i]/KI = 0, 1, 10, 100): (A) No change in VMAX, (B) VMAX increases 2-fold, (C) VMAX increases 5-fold, (D) VMAX decreases 2-fold, and (E) VMAX decreases 5-fold