Table 1.

List of PK model parameters [references are cited]

Parameter	Definition	Value
VBL (mL)	Volume of blood	20.3 [36, 37]
VPL (mL)	Volume of plasma	12.5 [36, 37]
VRM (mL)	Volume of remainder compartment	264 [36, 37]
VLI (mL)	Volume of liver	12.4 [36, 37]
QLI (mL/min)	Blood flow to liver	11.6 [36, 37]
QKI (mL/min)	Blood flow to kidneys	10.5 [36, 37]
QRM (mL/min)	Blood flow to remainder compartment	27.1 [36, 37]
KP, LI, KP, RM	Blood-to-tissue partition coefficients for liver and remainder compartments (unpublished in vivo data)	0.4
VGLM (mL)	Volume of glomerulus	0.08 [38]
VPTC (mL)	Volume of proximal tubule epithelial cells	1.03 [38]
VRBL (mL)	Volume of renal blood	0.375 [38]
VRPL (mL)	Volume of renal plasma	0.206 [38]
GFR (mL/min)	Glomerular filtration rate	2.2 [39]
VS1_1 (mL), QS1_1 (mL/min)	Volume and flow of filtrate in lumen of 1st sub-segment of S1 segment of proximal tubule	GFR
VS1_2 (mL), QS1_2 (mL/min)	Volume and flow of filtrate in lumen of 2nd sub-segment of S1 segment of proximal tubule	0.85 × GFR [17–19]
VS1_3 (mL), QS1_3 (mL/min)	Volume and flow of filtrate in lumen of 3rd sub-segment of S1 segment of proximal tubule	0.70 × GFR [17–19]
VS2+S3 (mL), QS2+S3 (mL/min)	Volume and flow of filtrate in lumen of S2 and S3 segments of proximal tubule	0.55 × GFR [17–19]
VLOH (mL), QLOH (mL/min)	Volume and flow of filtrate in lumen of Loop of Henle	0.33 × GFR [17–19]
VDistT+CD (mL), QDistT+CD (mL/min)	Volume and flow of filtrate in lumen of distal tubules and collecting ducts	0.18 × GFR [17–19]
VU (mL), QU (mL/min)	Volume and flow of urine	0.02 × GFR [17–19]
KM, MET (µg/mL)	Metabolic Michaelis-Menten affinity constant	63 [16, 40]
KM, BBM ((µg/mL)	Renal reabsorption Michaelis-Menten affinity constant at BBM	480 [29]
KM, BLM ((µg/mL)	Renal reabsorption Michaelis-Menten affinity constant at BLM	1092 [29]
VMAX,MET (µg/min)	Maximal metabolic capacity	670 [11]
VMAX,BBM (µg/min)	Maximal renal reabsorption capacity at BBM	1950 [11]
VMAX,BLM (µg/min)	Maximal renal reabsorption capacity at BLM	1101 [11]