Table 2.
Geometric mean values of VN antibodies in mice immunized YFE-1 or YFE-2E
| Antigen | Dose of antigen | GM (mIU/mL) (95% CI) | |||
|---|---|---|---|---|---|
| Pre-immune | Day 28 | Day 56 | % Responder† | ||
| YFE-1 | 20 | 172 (122–282) | 464 (401–545) | 1,972 (1,094–5,017) | 80 |
| 10 | 92 (65–147) | 557 (466–681) | 2,031 (325–8,437) | 70 | |
| 5 | 123 (79–215) | 528 (458–620) | 1,865 (1,318–2,793)* | 100 | |
| 2.5 | 108 (72–173) | 351 (281–450) | 1,065 (772–1,585) | 70 | |
| 1.25 | 126 (86–204) | 239 (195–304) | 655 (367–1,279) | 30 | |
| 0 | 116 (72–201) | 161 (121–245) | 104 (81–134) | 0 | |
| YFE-2E | 20 | 88 (64–123) | 1,236 (671–2,373)** | 2,036 (1,666–2,584) | 100 |
| 10 | 191 (136–300) | 671 (533–859) | 1,267 (891–1,922) | 80 | |
| 5 | 92 (65–130) | 844 (712–1,056)** | 918 (656–1,451) | 60 | |
| 2.5 | 125 (95–172) | 537 (455–651)** | 921 (727–1,220) | 60 | |
| 1.25 | 131 (106–162) | 469 (287–876)* | 654 (520–866) | 30 | |
| 0 | 120 (137–312) | 117 (81–186) | 70 (70–70) | 0 | |
CI = confidence interval; GM = geometric mean; VN = virus neutralizing; YFE = yellow fever virus envelope protein.
*
P < 0.05 and **P < 0.01 when VN values of two group received same dose of YFE-1 vs. YFE-2E on the same study day (Mann–Whitney test).
†
Percent of animals showed VN antibody values over 794 mIU/mL on study day 56.