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. 2018 Apr 13;9(28):19490–19507. doi: 10.18632/oncotarget.24626

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Copyright: © 2018 Trumpi et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) Left box-whisker plot showing the gene signature expression of NFκB in the LM subgroups. Right box-whisker plot showing the gene signature expression of NFκB in primary CRC classified via the CMS-classification. (B) Western Blots of whole cell lysates showing NFκB p65 expression, with GFP, H3 and β-actin as loading controls. (C) Western blots of whole cell lysates showing occludin expression in mono- and co-cultures with or without Sanguinarine 1 μM treatment for 48 hours. (D) Adherence assay showing the number of small cell clusters (≤5 cells) per condition with or without Sanguinarine 1 μM treatment for 48 hours, multiple t-tests, p<0.01. (F) Western blots of whole cell lysates showing decreased MMP7 expression with Sanguinarine 1 μM treatment and Batimastat 10 μM, for 48 hours.