Skip to main content
. 2018 Apr 13;9(28):19508–19524. doi: 10.18632/oncotarget.24628

Figure 6. Roles of klotho family in bladder cancer.

Figure 6

In urothelial carcinoma of the bladder, along with increase of tumor grade the expression level of KLα decrease and the expression levels of KLβ and KLγ increase. KLs are orchestrating to affect cancer progression. KLa acts as a tumor suppressor mediated by inhibition of the IGF-1/insulin signaling pathway and EMT. KLb acts as a tumor promotor mediated by regulation of FGF4 signaling pathway, phosphorylation of ERK1/2 and FRS2. Similarly, KLγ acts as a tumor promotor mediated by regulation of FGF4 signaling pathway, ERK1/2 pathway, and EMT.