Table 3. Cox regression analysis of prognostic factors for overall survival.
Variables | Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | ||
Gender | 0.39 | ||||||
Male | 1 | ||||||
Female | 1.7 | 0.5 - 6.0 | |||||
Age | 0.27 | ||||||
< 70 | 1 | ||||||
≥ 70 | 1.7 | 0.7 - 4.6 | |||||
T category | 0.099 | ||||||
Ta | 1 | ||||||
T1 | 2.5 | 0.8 - 7.8 | |||||
Tis | 4.5 | 1.1 - 18.1 | |||||
Tumor Grade | 0.05 | 0.61 | |||||
Low | 1 | 1 | |||||
High | 3 | 1.0 - 9.1 | 0.58 | 0.07 - 4.8 | |||
INF | < 0.0001 | 0.022 | |||||
No | 1 | 1 | |||||
Yes | 6.6 | 2.5 - 17.4 | 7.8 | 1.3 - 44.9 | |||
CIS | 0.034 | 0.45 | |||||
No | 1 | 1 | |||||
Yes | 2.8 | 1.1 - 7.5 | 1.8 | 0.4 - 8.3 | |||
LVI | 0.014 | 0.59 | |||||
No | 1 | 1 | |||||
Yes | 3.2 | 1.3 - 7.9 | 1.7 | 0.3 - 10.4 | |||
KLγ expression | 0.013 | 0.025 | |||||
Low | 1 | 1 | |||||
High | 3.6 | 1.2 - 10.9 | 4.3 | 1.2 - 15.3 |
The high expression level of KLγ was not an independent poor prognostic factor.
Abbreviations: KLγ, γ–klotho; INF, infiltration; CIS, carcinoma in situ; LVI, lymphovascular invasion; HR, hazard ratio; CI, confidence interval.