Table 3. Literature review of TP53 variant and prognostic analysis in DLBCL.

					TP53 mutation		17p deletion/TP53 loss		Mutation with17p deletion/TP53 loss
Treatment	Study	Year		Total cases	OS	PFS/DFS	OS	PFS/DFS	OS	PFS/DFS
CHOP era	Ichikawa A et al.	1997 [23]		102	poor
	Stokke T et al.	2001 [24]		94			poor
	Leroy K et al.	2002 [25]		69	poor
	Young KH et al.	2007 [26]		113	poor	NS	NS
	Stöcklein H et al.	2008 [27]		40	NS		NS		poor
	Young KH et al.	2008 [28]		477	poor
R-CHOP era	Xu-Monette ZY et al.	2012 [29]		506	poor	poor	NS	NS
	Asmar F et al.	2014 [30]		62	poor
	Fiskvik I et al.	2015 [31]		43			poor	poor
	Cao Y et al.	2016 [14]		165	poor	poor	poor	poor
	Zenz T et al.	2017 [32]		265	poor	poor
	Present study	2017	120	35 (Discovery cohort)	NS*	NS*	NS#	NS#	poor	poor
				85 (Validation cohort)	NS*	NS*	NS#	NS#	poor	poor

NS: not significant, ^*: TP53 mutation only, ^#: 17p deletion/TP53 loss only.